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Usage Information

Salt, sodium channels, and SGK1
David Pearce, Thomas R. Kleyman
David Pearce, Thomas R. Kleyman
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Salt, sodium channels, and SGK1

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Abstract

The hormone aldosterone increases extracellular fluid volume and blood pressure by activating epithelial Na+ channels (ENaCs). Serum- and glucocorticoid-induced kinase 1 (SGK1) is an aldosterone-stimulated signaling molecule that enhances distal nephron Na+ transport, in part by preventing the internalization of ENaCs from the plasma membrane. In this issue of the JCI, Zhang et al. demonstrate that SGK1 enhances transcription of the α subunit of ENaC by preventing histone methylation, providing an additional mechanism by which SGK1 increases ENaC-mediated Na+ transport in the distal nephron (see the related article beginning on page 773).

Authors

David Pearce, Thomas R. Kleyman

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 678 72
PDF 158 9
Figure 177 1
Citation downloads 171 0
Totals 1,184 82
Total Views 1,266
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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