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Usage Information

Principles of adoptive T cell cancer therapy
Carl H. June
Carl H. June
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Review Series

Principles of adoptive T cell cancer therapy

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Abstract

The transfusion of T cells, also called adoptive T cell therapy, is an effective treatment for viral infections and has induced regression of cancer in early-stage clinical trials. However, recent advances in cellular immunology and tumor biology are guiding new approaches to adoptive T cell therapy. For example, use of engineered T cells is being tested as a strategy to improve the functions of effector and memory T cells, and manipulation of the host to overcome immunotoxic effects in the tumor microenvironment has led to promising results in early-stage clinical trials. Challenges that face the field and must be addressed before adoptive T cell therapy can be translated into routine clinical practice are discussed.

Authors

Carl H. June

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Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
Text version 1,818 80
PDF 151 33
Figure 375 7
Citation downloads 115 0
Totals 2,459 120
Total Views 2,579
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ISSN: 0021-9738 (print), 1558-8238 (online)

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