Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of which contribute to aortic dilatation. This study demonstrates that mast cells, key participants in human allergic immunity, participate in AAA pathogenesis in mice. Mast cells were found to accumulate in murine AAA lesions. Mast cell–deficient
Jiusong Sun, Galina K. Sukhova, Min Yang, Paul J. Wolters, Lindsey A. MacFarlane, Peter Libby, Chongxiu Sun, Yadong Zhang, Jian Liu, Terri L. Ennis, Rebecca Knispel, Wanfen Xiong, Robert W. Thompson, B. Timothy Baxter, Guo-Ping Shi
Mast cell accumulation in elastase perfusion–induced AAA.