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An intrinsic host defense against HIV-1 integration?
Paul D. Bieniasz
Paul D. Bieniasz
Published February 1, 2007
Citation Information: J Clin Invest. 2007;117(2):302-304. https://doi.org/10.1172/JCI31290.
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Commentary

An intrinsic host defense against HIV-1 integration?

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Abstract

HSCs are one of only a few cell types that resist HIV-1 infection despite the presence of HIV-1 receptors. An increasing number of genes have been identified that can reduce the sensitivity of cultured cells to retrovirus infection, and in this issue of the JCI, Zhang et al. identify p21Waf1/Cip1/Sdi1 (p21) as a gene product that can influence the sensitivity of HSCs to HIV-1 infection (see the related article beginning on page 473). Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses.

Authors

Paul D. Bieniasz

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