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Usage Information

Infectious disease, the innate immune response, and fibrosis
Alessia Meneghin, Cory M. Hogaboam
Alessia Meneghin, Cory M. Hogaboam
Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):530-538. https://doi.org/10.1172/JCI30595.
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Review Series

Infectious disease, the innate immune response, and fibrosis

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Abstract

The unrelenting and destructive progression of most fibrotic responses in the pulmonary, cardiovascular, integumentary, and alimentary systems remains a major medical challenge for which therapies are desperately needed. The pathophysiology of fibrosis remains an enigma, but considerable research and debate surrounds the question of whether chronic inflammation is the key driver of unrestrained wound healing (i.e., the fibrotic response) in these and other organ systems. This Review describes how infectious pathogens, chronic inflammation, and unrestrained fibroproliferation are likely to be part of a dynamic, unrelenting process propelling human fibrotic diseases.

Authors

Alessia Meneghin, Cory M. Hogaboam

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,038 60
PDF 87 30
Figure 196 2
Table 62 0
Citation downloads 69 0
Totals 1,452 92
Total Views 1,544
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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