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Usage Information

Islet β cell failure in type 2 diabetes
Marc Prentki, Christopher J. Nolan
Marc Prentki, Christopher J. Nolan
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Review Series

Islet β cell failure in type 2 diabetes

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Abstract

The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of β cell mass and for enhanced β cell performance. The importance of genetic, intrauterine, and environmental factors in the determination of “susceptible” islets and overall risk for T2D is reviewed. The likely mechanisms of β cell failure are discussed within the two broad categories: those with initiation and those with progression roles.

Authors

Marc Prentki, Christopher J. Nolan

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Usage data is cumulative from February 2025 through February 2026.

Usage JCI PMC
Text version 4,500 1,501
PDF 373 214
Figure 618 10
Supplemental data 91 2
Citation downloads 231 0
Totals 5,813 1,727
Total Views 7,540
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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