PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Brian N. Finck, Daniel P. Kelly
Brian N. Finck, Daniel P. Kelly
Published March 1, 2006
Citation Information: J Clin Invest. 2006;116(3):615-622. https://doi.org/10.1172/JCI27794.
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Review Series

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

Abstract

Members of the PPARĪ³ coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

Authors

Brian N. Finck, Daniel P. Kelly

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Figure 2

The PGC-1 gene regulatory cascade.

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The PGC-1 gene regulatory cascade. The schematic indicates the upstream ...
The schematic indicates the upstream signaling events and downstream gene regulatory actions of the inducible PGC-1 coactivators, using PGC-1α as the representative factor. The interaction of PGC-1α with its cognate transcription factor targets is shown linked to specific organ systems. For example, PGC-1α coactivates members of the PPAR nuclear receptor transcription factor family, to activate the expression of genes involved in mitochondrial fatty acid oxidation. The signaling pathways shown at the top of each organ system transduce extracellular physiologic and nutritional stimuli to the expression and/or activity of PGC-1α. LXR, liver X receptor; TAG, triacylglycerol; RXR, retinoid X receptor; mtDNA, mitochondrial DNA; OXPHOS, oxidative phosphorylation.