Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Minding the gaps to promote thrombus growth and stability
Lawrence F. Brass, … , Li Zhu, Timothy J. Stalker
Lawrence F. Brass, … , Li Zhu, Timothy J. Stalker
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3385-3392. https://doi.org/10.1172/JCI26869.
View: Text | PDF
Review Series

Minding the gaps to promote thrombus growth and stability

  • Text
  • PDF
Abstract

Efforts to understand the role of platelets in hemostasis and thrombosis have largely focused on the earliest events of platelet activation, those that lead to aggregation. Although much remains to be learned about those early events, this Review examines a later series of events: the interactions between platelets that can only occur once aggregation has begun, bringing platelets into close contact with each other, creating a protected environment in the gaps between aggregated platelets, and fostering the continued growth and stability of the hemostatic plug.

Authors

Lawrence F. Brass, Li Zhu, Timothy J. Stalker

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Events in the gap. The gap between activated platelets in a growing thro...
Events in the gap. The gap between activated platelets in a growing thrombus is small enough for integrins and other cell adhesion molecules (CAMs) to interact and for interactions to occur between receptors such as Eph kinases and their cell surface ligands, known as ephrins. The space between platelets also provides a protected environment in which soluble agonists (ADP and TxA2) and the proteolytically shed exodomains of platelet surface proteins can accumulate. Signaling by ephrins and Eph kinases promotes integrin engagement and outside-in signaling. The mechanical forces generated by the contraction of actin/myosin filaments may compress the space between platelets, improving contacts and increasing the concentration of soluble agonists. The binding of cell adhesion molecules to their partners may limit diffusion into and out of the space between platelets in addition to stabilizing platelet/platelet interactions.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts