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Usage Information

The molecular mechanisms that control thrombopoiesis
Kenneth Kaushansky
Kenneth Kaushansky
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3339-3347. https://doi.org/10.1172/JCI26674.
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Review Series

The molecular mechanisms that control thrombopoiesis

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Abstract

Our understanding of thrombopoiesis — the formation of blood platelets — has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal and expansion of HSCs, through stimulation of the proliferation of megakaryocyte progenitor cells, to support of the maturation of these cells into platelet-producing cells. The molecular and cellular mechanisms through which thrombopoietin affects platelet production provide new insights into the interplay between intrinsic and extrinsic influences on hematopoiesis and highlight new opportunities to translate basic biology into clinical advances.

Authors

Kenneth Kaushansky

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Usage data is cumulative from March 2022 through March 2023.

Usage JCI PMC
Text version 2,399 3,562
PDF 276 207
Figure 758 39
Citation downloads 86 0
Totals 3,519 3,808
Total Views 7,327

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