Citations to this article

The survival kinases Akt and Pim as potential pharmacological targets
Ravi Amaravadi, Craig B. Thompson
Ravi Amaravadi, Craig B. Thompson
Published October 3, 2005
Citation Information: J Clin Invest. 2005;115(10):2618-2624. https://doi.org/10.1172/JCI26273.
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The survival kinases Akt and Pim as potential pharmacological targets

Abstract

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT–dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.

Authors

Ravi Amaravadi, Craig B. Thompson

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