Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.

A Wiersma; B Hirsch; A Tsafriri; R G Hanssen; M Van de Kant; H J Kloosterboer; M Conti; A J Hsueh

doi:10.1172/JCI2566

Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Department of Pharmacology, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands. a.wiersma@organon.oss.akzonobel.nl

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Published in Volume 102, Issue 3 on August 1, 1998
J Clin Invest. 1998;102(3):532–537. https://doi.org/10.1172/JCI2566.
© 1998 The American Society for Clinical Investigation

Published August 1, 1998 - Version history

During each reproductive cycle, a preovulatory surge of gonadotropins induces meiotic maturation of the oocyte in the preovulatory follicle followed by ovulation. Although gonadotropins stimulate cAMP production in somatic cells of the follicle, a decrease in intra-oocyte cAMP levels is required for resumption of meiosis in oocytes. Based on the observed compartmentalization of the cAMP-degrading enzyme, phosphodiesterase, in follicular somatic and germ cells, inhibitors of phosphodiesterase 3 were used to block meiosis in ovulating oocytes in rodents. By this strategy, we demonstrated that fertilization and pregnancy could be prevented without disturbing follicle rupture and normal estrous cyclicity. In contrast to conventional contraceptive pills that disrupt ovarian steroidogenesis and reproductive cycles, the present strategy achieves effective contraception by selective blockage of oocyte maturation and development without alterations in ovulation and reproductive cyclicity.

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Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.

A Wiersma, B Hirsch, A Tsafriri, R G Hanssen, M Van de Kant, H J Kloosterboer, M Conti, and A J Hsueh

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Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.

A Wiersma, B Hirsch, A Tsafriri, R G Hanssen, M Van de Kant, H J Kloosterboer, M Conti, and A J Hsueh

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