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Of mice and men: the iron age
Sophie Vaulont, … , Lydie Viatte, Axel Kahn
Sophie Vaulont, … , Lydie Viatte, Axel Kahn
Published August 1, 2005
Citation Information: J Clin Invest. 2005;115(8):2079-2082. https://doi.org/10.1172/JCI25642.
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Commentary

Of mice and men: the iron age

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Abstract

Recently, mutations causing juvenile hemochromatosis have been identified in a novel gene, hemojuvelin (HJV), located on chromosome 1. Mouse models of this disease have now been developed by 2 groups, Huang et al. and Niederkofler et al., through targeted disruption of the Hjv gene (see the related articles beginning on pages 2180 and 2187). These mutant mice will allow further investigation into the role of HJV in the regulation of iron homeostasis, a role that to date remains elusive.

Authors

Sophie Vaulont, Dan-Qing Lou, Lydie Viatte, Axel Kahn

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