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Usage Information

Lessons learned from cancer may help in the treatment of pulmonary hypertension
Serge Adnot
Serge Adnot
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1461-1463. https://doi.org/10.1172/JCI25399.
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Commentary

Lessons learned from cancer may help in the treatment of pulmonary hypertension

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Abstract

Hyperplasia of pulmonary artery SMCs (PASMCs) is a pathological hallmark of pulmonary arterial hypertension (PAH). In this issue of the JCI, McMurtry et al. report that adenovirus-mediated overexpression of survivin — a multipotent inhibitor of apoptosis — induces PAH in rats, whereas inhalation of an adenovirus vector encoding a mutant survivin gene with dominant-negative properties reverses established monocrotaline-induced PAH. These findings raise important issues regarding the role of survivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies.

Authors

Serge Adnot

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Usage data is cumulative from November 2024 through November 2025.

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