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Immunopathogenesis and therapy of cutaneous T cell lymphoma
Ellen J. Kim, Stephen Hess, Stephen K. Richardson, Sara Newton, Louise C. Showe, Bernice M. Benoit, Ravi Ubriani, Carmela C. Vittorio, Jacqueline M. Junkins-Hopkins, Maria Wysocka, and Alain H. Rook
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First published March 1, 2007 - More info
J Clin Invest. 2007;117(3):836–836. https://doi.org/10.1172/JCI24826C1.
© 2007 The American Society for Clinical Investigation
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Abstract
Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of CTCLs and are characterized by malignant CD4+/CLA+/CCR4+ T cells that also lack the usual T cell surface markers CD7 and/or CD26. As MF/SS advances, the clonal dominance of the malignant cells results in the expression of predominantly Th2 cytokines, progressive immune dysregulation in patients, and further tumor cell growth. This review summarizes recent insights into the pathogenesis and immunobiology of MF/SS and how these have shaped current therapeutic approaches, in particular the growing emphasis on enhancement of host antitumor immune responses as the key to successful therapy.
Authors
Ellen J. Kim, Stephen Hess, Stephen K. Richardson, Sara Newton, Louise C. Showe, Bernice M. Benoit, Ravi Ubriani, Carmela C. Vittorio, Jacqueline M. Junkins-Hopkins, Maria Wysocka, Alain H. Rook
Original citation: J. Clin. Invest.115:798-812 (2005). doi:10.1172/JCI200524826.
Citation for this corrigendum: J. Clin. Invest.117:836 (2007). doi:10.1172/JCI24826C1.
During the preparation of the manuscript, the original source of information appearing in Table 2 and TNMB classification for MF and SS was incorrectly cited. The correct citation for each appears below.
Adapted with permission from Archives of Dermatology (11).
The correct reference appears below.
11. Lamberg, S.I., and Bunn, P.A., Jr. 1979. Cutaneous T-cell lymphomas. Summary of the Mycosis Fungoides Cooperative Group-National Cancer Institute Workshop. Arch. Dermatol.115:1103-1105.
The authors regret this error.
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