Finding schizophrenia genes
George Kirov, … , Michael C. O’Donovan, Michael J. Owen
George Kirov, … , Michael C. O’Donovan, Michael J. Owen
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1440-1448. https://doi.org/10.1172/JCI24759.
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Finding schizophrenia genes

Abstract

Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.

Authors

George Kirov, Michael C. O’Donovan, Michael J. Owen

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Figure 3

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Chromosome 22 and the location of the VCFS deletions. The positions of c...
Chromosome 22 and the location of the VCFS deletions. The positions of candidate genes within the typically deleted region that are discussed in this paper are also indicated. The frequencies of the deleted regions are taken from Shaikh et al. (103).