Soy diet worsens heart disease in mice
Brian L. Stauffer, … , Elizabeth D. Luczak, Leslie A. Leinwand
Brian L. Stauffer, … , Elizabeth D. Luczak, Leslie A. Leinwand
Published January 4, 2006
Citation Information: J Clin Invest. 2006;116(1):209-216. https://doi.org/10.1172/JCI24676.
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Research Article Cardiology

Soy diet worsens heart disease in mice

Abstract

We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the α-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of β-myosin heavy chain, inactivation of glycogen synthase kinase 3β (GSK3β), and caspase-3 activation.

Authors

Brian L. Stauffer, John P. Konhilas, Elizabeth D. Luczak, Leslie A. Leinwand

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Figure 1

Cardiac growth due to transgene expression is modified by sex and diet at 8 months of age.

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Cardiac growth due to transgene expression is modified by sex and diet a...
(A) VW normalized to body growth, assessed by TL. *Significant transgene effect with each sex and diet combination (P < 0.005 for each). †Significant sex effect by diet in both WT and HCM mice (P < 0.0001). #Significant diet effect (P < 0.05) between groups except in WT males. (B) There is a diet-dependent difference in the degree of hypertrophy in the male mice while there is no diet-dependent difference in the female animals. ΧP < 0.01 versus male casein. n = 21–35 in each group. HCM, transgenic HCM mice. Mean ± SEM.