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Defining smooth muscle cells and smooth muscle injury
William M. Mahoney Jr., Stephen M. Schwartz
William M. Mahoney Jr., Stephen M. Schwartz
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):221-224. https://doi.org/10.1172/JCI24272.
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Commentary

Defining smooth muscle cells and smooth muscle injury

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Abstract

For 3 decades, terms such as synthetic phenotype and contractile phenotype have been used to imply the existence of a specific mechanism for smooth muscle cell (SMC) responses to injury. In this issue of the JCI, Hendrix et al. offer a far more precise approach to examining the mechanisms of SMC responses to injury, focused not on general changes in phenotype but on effects of injury on a single promoter element, the CArG [CC(A/T)6GG] box, in a single gene encoding smooth muscle (SM) α-actin. Since CArG box structures are present in some, but not all, SMC genes, these data suggest that we may be progressing toward establishing a systematic, molecular classification of both SMC subsets and the response of SMCs to different injuries.

Authors

William M. Mahoney Jr., Stephen M. Schwartz

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