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Marfan syndrome and mitral valve prolapse
Arthur E. Weyman, Marielle Scherrer-Crosbie
Arthur E. Weyman, Marielle Scherrer-Crosbie
Published December 1, 2004
Citation Information: J Clin Invest. 2004;114(11):1543-1546. https://doi.org/10.1172/JCI23701.
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Commentary

Marfan syndrome and mitral valve prolapse

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Abstract

Mitral valve prolapse (MVP), an abnormal displacement into the left atrium of a thickened and redundant mitral valve during systole, is a relatively frequent abnormality in humans and may be associated with serious complications. A recent study implicates fibrillin-1, a component of extracellular matrix microfibrils, in the pathogenesis of a murine model of MVP. This investigation represents an initial step toward understanding the mechanisms involved in human MVP disease and the development of potential treatments.

Authors

Arthur E. Weyman, Marielle Scherrer-Crosbie

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