Adenosine and ATP: traffic regulators in the kidney
Wilhelm Kriz
Wilhelm Kriz
Published September 1, 2004
Citation Information: J Clin Invest. 2004;114(5):611-613. https://doi.org/10.1172/JCI22669.
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Commentary

Adenosine and ATP: traffic regulators in the kidney

Abstract

Glomerular filtration in the kidney is a continuous process that acts in concert with tubular reabsorption to prevent derangements of body fluid composition. Filtration is regulated by systemic factors, but it is also controlled by an intrinsic mechanism based on the anatomical connection between the distal nephron and the glomerular arterioles. Facing the threat of urinary salt loss, this mechanism causes vasoconstriction and reduces filtration by generating adenosine through the hydrolysis of nucleotide precursors such as 5′-AMP and possibly ATP .

Authors

Wilhelm Kriz

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Figure 2

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Schematic showing the structural and functional relationships within the...
Schematic showing the structural and functional relationships within the JGA. The MD cells are shown in brown, the extraglomerular mesangium in blue, the VSMCs in magenta, the renin-producing cells in green, the fibroblasts of the adjacent interstitium in yellow, and the blood vessels in red. Note that both signaling pathways from the MD pass the extraglomerular mesangium, either to reach the VSMCs (I) to regulate filtration or the renin-producing cells (II) to mediate renin secretion.