Adenosine and ATP: traffic regulators in the kidney
Wilhelm Kriz
Wilhelm Kriz
Published September 1, 2004
Citation Information: J Clin Invest. 2004;114(5):611-613. https://doi.org/10.1172/JCI22669.
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Commentary

Adenosine and ATP: traffic regulators in the kidney

Abstract

Glomerular filtration in the kidney is a continuous process that acts in concert with tubular reabsorption to prevent derangements of body fluid composition. Filtration is regulated by systemic factors, but it is also controlled by an intrinsic mechanism based on the anatomical connection between the distal nephron and the glomerular arterioles. Facing the threat of urinary salt loss, this mechanism causes vasoconstriction and reduces filtration by generating adenosine through the hydrolysis of nucleotide precursors such as 5′-AMP and possibly ATP .

Authors

Wilhelm Kriz

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Figure 1

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Structural organization of the nephron. Blood vessels are shown in red; ...
Structural organization of the nephron. Blood vessels are shown in red; the glomerulus and the tubular system in gray. The afferent arteriole feeds the glomerular capillary network, where filtration of the blood occurs. The glomerular filtrate is processed as it travels through the different tubular segments. At the cell plaque of the MD, with which the TAL touches the vascular pole of its glomerulus, tubular fluid composition is sensed and paracrine signals are conveyed to smooth muscle and renin-producing cells of the afferent arteriole.