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Usage Information

The emergence of Lyme disease
Allen C. Steere, Jenifer Coburn, Lisa Glickstein
Allen C. Steere, Jenifer Coburn, Lisa Glickstein
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Review Series

The emergence of Lyme disease

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Abstract

Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern.

Authors

Allen C. Steere, Jenifer Coburn, Lisa Glickstein

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 5,075 6,753
PDF 577 103
Figure 1,053 17
Table 156 0
Supplemental data 107 20
Citation downloads 275 0
Totals 7,243 6,893
Total Views 14,136
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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