Dengue: defining protective versus pathologic immunity
Alan L. Rothman
Alan L. Rothman
Published April 1, 2004
Citation Information: J Clin Invest. 2004;113(7):946-951. https://doi.org/10.1172/JCI21512.
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Review Series

Dengue: defining protective versus pathologic immunity

Abstract

Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.

Authors

Alan L. Rothman

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Postulated pathologic mechanisms of DENV-reactive immune responses in th...

Postulated pathologic mechanisms of DENV-reactive immune responses in the development of DHF