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Usage Information

Epithelial-mesenchymal transition and its implications for fibrosis
Raghu Kalluri, Eric G. Neilson
Raghu Kalluri, Eric G. Neilson
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Epithelial-mesenchymal transition and its implications for fibrosis

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Abstract

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.

Authors

Raghu Kalluri, Eric G. Neilson

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Usage data is cumulative from December 2024 through December 2025.

Usage JCI PMC
Text version 3,811 686
PDF 230 173
Figure 318 4
Table 63 0
Citation downloads 133 0
Totals 4,555 863
Total Views 5,418
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