Obesity-induced inflammatory changes in adipose tissue
Kathryn E. Wellen, Gökhan S. Hotamisligil
Kathryn E. Wellen, Gökhan S. Hotamisligil
Published December 15, 2003
Citation Information: J Clin Invest. 2003;112(12):1785-1788. https://doi.org/10.1172/JCI20514.
View: Text | PDF
Commentary

Obesity-induced inflammatory changes in adipose tissue

Abstract

Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.

Authors

Kathryn E. Wellen, Gökhan S. Hotamisligil

×

Full Text PDF | Download (2.76 MB)