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Research LetterIn-Press PreviewGastroenterologyOncology
Open Access | 
10.1172/JCI201216
Genomic characterization of therapy-associated polyposis reveals an alkylating mutational signature from prior treatment
Yashika Parashar,1 Zsofia Sztupinszki,2 Aurel György Prósz,2 Xiaolu Wang,1 Pratyusha Bala,1 Shweta Kiran Cavale,1 Chinedu Ukaegbu,1 Sapna Syngal,1 Asaf Maoz,1 Leah H. Biller,1 Ramona Lim,1 Matthew B. Yurgelun,1 Zoltan Szallasi,2 and Nilay S. Sethi1
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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Sztupinszki, Z.
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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Szallasi, Z.
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1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America
2Danish Cancer Institute, Copenhagen, Denmark
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Sethi, N.
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Published August 4, 2026 - More info
Copyright © 2026, Parashar et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)