A novel role for uroguanylin in the regulation of sodium balance
Leonard R. Forte
Leonard R. Forte
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Commentary

A novel role for uroguanylin in the regulation of sodium balance

Abstract

Uroguanylin is a peptide hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. A new study demonstrates that mice deficient in uroguanylin have blunted urinary sodium excretion responses to oral sodium loads in addition to elevated blood pressure (see related article beginning on page 1244). A physiological role for uroguanylin is discussed, linking the intestine and kidney in an endocrine axis for the maintenance of sodium balance.

Authors

Leonard R. Forte

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Figure 1

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Primary structures of guanylin, uroguanylin, and bacterial ST peptides. ...
Primary structures of guanylin, uroguanylin, and bacterial ST peptides. Single letter abbreviations for the amino acids are used. The peptides are aligned using the conserved cysteine residues found in the three classes of peptides. Sequences for Zebrafish and Fugu peptides were derived from their respective genome sequencing projects, and those for eel peptides were taken from Yuge et al. (17).