Advertisement
Research LetterIn-Press PreviewMetabolismOncology
Open Access | 
10.1172/JCI198821
Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism
Johnathan R. Kent,1 Keene L. Abbott,2 Rachel Nordgren,3 Amy Deik,4 Nupur K. Das,5 Millenia Waite,2 Tenzin Kunchok,2 Anna Shevzov-Zebrun,2 Nathaniel Christiansen,1 Amir Sadek,1 Darren S. Bryan,1 Mark K. Ferguson,1 Jessica S. Donington,1 Alexander Muir,6 Yatrik M. Shah,5 Clary B. Clish,4 Matthew G. Vander Heiden,2 Maria Lucia L. Madariaga,1 and Peggy P. Hsu7
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Kent, J. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Abbott, K. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Nordgren, R. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Deik, A. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Das, N. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Waite, M. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Kunchok, T. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Shevzov-Zebrun, A. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Christiansen, N. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Sadek, A. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Bryan, D. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Ferguson, M. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Donington, J. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Muir, A. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by
Shah, Y.
in:
PubMed
|
Google Scholar
|
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by
Clish, C.
in:
PubMed
|
Google Scholar
|
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by
Vander Heiden, M.
in:
PubMed
|
Google Scholar
|
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Madariaga, M. in: PubMed | Google Scholar
1Department of Surgery, University of Chicago, Chicago, United States of America
2Department of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America
3Department of Public Health Sciences, University of Chicago, Chicago, United States of America
4Broad Institute, Cambridge, United States of America
5Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, United States of America
6Ben May Department of Cancer Research, University of Chicago, Chicago, United States of America
7Department of Internal Medicine, University of Michigan, Ann Arbor, United States of America
Find articles by Hsu, P. in: PubMed | Google Scholar
Published January 27, 2026 - More info
Copyright © 2026, Kent et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)