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Usage Information

Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair
Ketty Schwartz, Jean-Jacques Mercadier
Ketty Schwartz, Jean-Jacques Mercadier
Published September 1, 2003
Citation Information: J Clin Invest. 2003;112(5):652-654. https://doi.org/10.1172/JCI19632.
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Commentary

Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair

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Abstract

It has long been noted that while patients with familial hypertrophic cardiomyopathy due to cardiac troponin T (cTnT) mutations often suffer sudden cardiac death, they do not develop significant ventricular hypertrophy, suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study has revealed that a single missense mutation in cTnT causes a striking disruption to energy metabolism, leading to cardiomyopathy.

Authors

Ketty Schwartz, Jean-Jacques Mercadier

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