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Research LetterIn-Press PreviewNephrologyOncology Open Access | 10.1172/JCI193567

Identification of serum protein biomarkers for clear cell renal cell carcinoma using patient-derived xenografts

Dalin Zhang,1 Chun-Lung Chiu,1 Fernando Jose Garcia Marques,2 Abel Bermudez,2 Christian R. Hoerner,3 Nicholas Hadi,1 Elise Wang,1 Thomas J. Metzner,1 Ludimila Trabanino,1 John T. Leppert,1 Hongjuan Zhao,1 Robert Tibshirani,4 Alice C. Fan,1 Sharon J. Pitteri,2 and James D. Brooks1

1Department of Urology, Stanford University School of Medicine, Stanford, United States of America

2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

3Canary Center at the Stanford School of Medicine, Stanford University School of Medicine, Stanford, United States of America

4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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1Department of Urology, Stanford University School of Medicine, Stanford, United States of America

2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

3Canary Center at the Stanford School of Medicine, Stanford University School of Medicine, Stanford, United States of America

4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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1Department of Urology, Stanford University School of Medicine, Stanford, United States of America

2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

3Canary Center at the Stanford School of Medicine, Stanford University School of Medicine, Stanford, United States of America

4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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1Department of Urology, Stanford University School of Medicine, Stanford, United States of America

2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

3Canary Center at the Stanford School of Medicine, Stanford University School of Medicine, Stanford, United States of America

4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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2Department of Radiology, Stanford University School of Medicine, Stanford, United States of America

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4Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, United States of America

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Published November 4, 2025 - More info

J Clin Invest. https://doi.org/10.1172/JCI193567.
Copyright © 2025, Zhang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published November 4, 2025 - Version history
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