Blood-storage duration affects hematological and metabolic profiles in patients with sickle cell disease receiving transfusions

¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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¹Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, United States of America

²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States of America

³Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, United States of America

⁵Department of Ophthalmology, Duke University School of Medicine, Durham, United States of America

⁶Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, United States of America

⁷Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, United States of America

⁸Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States of America

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