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Research LetterIn-Press PreviewCardiologyGenetics
Open Access | 
10.1172/JCI192057
Functional interrogation of contextually-correct MYH7 variants using CRaTER-flox geneediting and contractility profiling
Alexander M. Loiben,1 Wei-Ming Chien,1 Ashley McKinstry,1 Dania Ahmed,1 Matthew C. Childers,2 Michael Regnier,2 Charles E. Murry,3 and Kai-Chun Yang1
1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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1Department of Medicine/Cardiology, University of Washington, Seattle, United States of America
2Department of Bioengineering, University of Washington, Seattle, United States of America
3Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, United States of America
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Published November 25, 2025 - More info
Copyright © 2025, Loiben et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)