DNA vaccines and apoptosis: to kill or not to kill?
Wolfgang W. Leitner, Nicholas P. Restifo
Wolfgang W. Leitner, Nicholas P. Restifo
Published July 1, 2003
Citation Information: J Clin Invest. 2003;112(1):22-24. https://doi.org/10.1172/JCI19069.
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Commentary

DNA vaccines and apoptosis: to kill or not to kill?

Abstract

The apoptotic machinery has become the latest target of vaccinologists attempting to improve the efficacy of DNA vaccines. While workers have previously sought to induce apoptotic death in transfected DCs as a means to activate immunity, a new approach (see related article on pages 109–117) instead seeks to delay apoptosis in host DCs after DNA vaccination.

Authors

Wolfgang W. Leitner, Nicholas P. Restifo

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