Impact of SGLT2 inhibitors on cerebrospinal fluid dynamics and implications for hydrocephalus management
Nishanth S. Sadagopan, … , Amy B. Heimberger, Stephen T. Magill
Nishanth S. Sadagopan, … , Amy B. Heimberger, Stephen T. Magill
Published June 10, 2025
Citation Information: J Clin Invest. 2025;135(15):e188584. https://doi.org/10.1172/JCI188584.
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Research Letter Aging Neuroscience

Impact of SGLT2 inhibitors on cerebrospinal fluid dynamics and implications for hydrocephalus management

Abstract

Authors

Nishanth S. Sadagopan, Rushmin Khazanchi, Rishi Jain, Amy B. Heimberger, Stephen T. Magill

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Figure 1

Effect of SGLT2 inhibition on ventricular size.

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Effect of SGLT2 inhibition on ventricular size. (A) Axial and coronal CT...
(A) Axial and coronal CT showing callosal angle at the splenium and anterior commissure before (left) and after SGLT2 inhibition (right). (B) Imaging timeline after VPS placement and initiation of SGLT2 inhibition. (C) Quantification of change in callosal angle before and after SGLT2 inhibition (2-tailed t test, P = 0.0225).