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ResearchIn-Press PreviewGastroenterologyImmunology
Open Access | 
10.1172/JCI183093
NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models
Se Hyeon Park,1 Dae Hee Cheon,2 Yu-Mi Kim,1 Yeji Choi,2 Yong-Joon Cho,3 Bong-Ki Hong,1 Sang-Hyun Cho,4 Mi‑Na Kweon,5 Hyug Moo Kwon,6 Eugene B. Chang,7 Donghyun Kim,2 and Wan-Uk Kim1
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
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1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
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1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
Find articles by Kim, Y. in: PubMed | Google Scholar
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
Find articles by Choi, Y. in: PubMed | Google Scholar
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
Find articles by Cho, Y. in: PubMed | Google Scholar
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
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1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
Find articles by Cho, S. in: PubMed | Google Scholar
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
Find articles by Kweon, M. in: PubMed | Google Scholar
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
Find articles by Kwon, H. in: PubMed | Google Scholar
1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
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Chang, E.
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1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
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Kim, D.
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1Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Molecular Bioscience, Kangwon National University, Chuncheon, Korea, Republic of
4School of Biological Sciences, Seoul National University, Seoul, Korea, Republic of
5Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of
6Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
7Department of Medicine, Section of Gastroenterology, University of Chicago IBD Research Center, Chicago, United States of America
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Kim, W.
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Published July 15, 2025 - More info
Copyright © 2025, Park et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)