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Timing of antiretroviral therapy initiation affects intact HIV reservoirs following analytical treatment interruption
Maegan R. Manning, … , Susan Moir, Tae-Wook Chun
Maegan R. Manning, … , Susan Moir, Tae-Wook Chun
Published October 15, 2024
Citation Information: J Clin Invest. 2024;134(20):e181632. https://doi.org/10.1172/JCI181632.
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Research Letter AIDS/HIV

Timing of antiretroviral therapy initiation affects intact HIV reservoirs following analytical treatment interruption

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Abstract

Authors

Maegan R. Manning, Jana Blazkova, Jesse S. Justement, Victoria Shi, Brooke D. Kennedy, M. Ali Rai, Catherine A. Seamon, Kathleen Gittens, Michael C. Sneller, Susan Moir, Tae-Wook Chun

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Figure 1

Immunologic and virologic parameters.

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Immunologic and virologic parameters.
Intact and defective HIV proviral ...
Intact and defective HIV proviral DNA (A), correlations (Spearman’s method) between IPD fold change (post-ATI1/pre-ATI) and pre-ATI IPD (B) or plasma viremia during ATI (C), pre-ATI and post-ATI1 residual plasma viremia (D), pre-ATI and post-ATI1 levels of PD-L1 and perforin (E), frequency of MAIT cells (F), polyfunctional HIV-specific T cell response (G), and percentage of CD56dimCD16+CD57+ NK cells (H). Open symbols indicate values under the limit of detection, and black bars indicate the geometric mean or median. P values were determined using Wilcoxon’s matched-pairs signed rank test (A, D, and E) and adjusted using the Holm-Bonferroni method (A) and the Mann-Whitney U test (F–H).

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