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Usage Information

Disrupted TGF-β signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells
Rongbo Li
Rongbo Li
Published March 15, 2024
Citation Information: J Clin Invest. 2024;134(6):e178562. https://doi.org/10.1172/JCI178562.
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Commentary

Disrupted TGF-β signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells

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Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However, a notable gap exists in the involvement of AT1 cells, which constitute a majority of the alveolar surface area. In this issue of the JCI, Callaway and colleagues explored the role of TGF-β signaling in AT1 cells for managing the AT1-to-AT2 transition and its involvement in the integration of mechanical forces with the pulmonary matrisome during development. The findings implicate AT1 cells in the pathogenesis of BPD.

Authors

Rongbo Li

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