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Usage Information

Yoda1 opens the lymphatic path for craniosynostosis therapy
Aleksanteri Aspelund, Kari Alitalo
Aleksanteri Aspelund, Kari Alitalo
Published February 15, 2024
Citation Information: J Clin Invest. 2024;134(4):e176858. https://doi.org/10.1172/JCI176858.
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Commentary

Yoda1 opens the lymphatic path for craniosynostosis therapy

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Abstract

The rediscovery of meningeal lymphatic vessels (MLVs) has sparked research interest in their function in numerous neurological pathologies. Craniosynostosis (CS) is caused by a premature fusion of cranial sutures during development. In this issue of the JCI, Matrongolo and colleagues show that Twist1-haploinsufficient mice that develop CS exhibit raised intracranial pressure, diminished cerebrospinal fluid (CSF) outflow, and impaired paravascular CSF-brain flow; all features that were associated with MLV defects and exacerbated pathology in mouse models of Alzheimer’s disease. Activation of the mechanosensor Piezo1 with Yoda1 restored MLV function and CSF perfusion in CS models and in aged mice, opening an avenue for further development of therapeutics.

Authors

Aleksanteri Aspelund, Kari Alitalo

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,687 420
PDF 236 103
Figure 130 0
Citation downloads 143 0
Totals 2,196 523
Total Views 2,719

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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