Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes
Gianfranco Di Giuseppe, Laura Soldovieri, Gea Ciccarelli, Pietro Manuel Ferraro, Giuseppe Quero, Francesca Cinti, Umberto Capece, Simona Moffa, Enrico Celestino Nista, Antonio Gasbarrini, Andrea Mari, Sergio Alfieri, Vincenzo Tondolo, Alfredo Pontecorvi, Jens Juul Holst, Andrea Giaccari, Teresa Mezza
Gianfranco Di Giuseppe, Laura Soldovieri, Gea Ciccarelli, Pietro Manuel Ferraro, Giuseppe Quero, Francesca Cinti, Umberto Capece, Simona Moffa, Enrico Celestino Nista, Antonio Gasbarrini, Andrea Mari, Sergio Alfieri, Vincenzo Tondolo, Alfredo Pontecorvi, Jens Juul Holst, Andrea Giaccari, Teresa Mezza
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Research Letter Endocrinology Metabolism

Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes

Abstract

Authors

Gianfranco Di Giuseppe, Laura Soldovieri, Gea Ciccarelli, Pietro Manuel Ferraro, Giuseppe Quero, Francesca Cinti, Umberto Capece, Simona Moffa, Enrico Celestino Nista, Antonio Gasbarrini, Andrea Mari, Sergio Alfieri, Vincenzo Tondolo, Alfredo Pontecorvi, Jens Juul Holst, Andrea Giaccari, Teresa Mezza

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Figure 1

Functional defects predict diabetes onset after pancreatoduodenectomy despite normal hormone secretion.

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Functional defects predict diabetes onset after pancreatoduodenectomy de...
Glucose (A), insulin (B), C-peptide (C), GLP-1 (D), and GIP (E) levels during MMT in the post-NGT (solid lines, green circles), post-IGT (dotted lines, yellow circles), and post-DM (dotted-dashed lines, red circles) groups. MMT-derived βCGS (F), HC-derived βCGS (G), and IE (H) in the post-NGT (green), post-IGT (yellow), and post-DM (red) groups. *P < 0.05.