Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force

Quentin McAfee; Matthew A. Caporizzo; Keita Uchida; Kenneth C. Bedi Jr.; Kenneth B. Margulies; Zolt Arany; Benjamin L. Prosser

doi:10.1172/JCI170196

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Research Letter In-Press Preview Cardiology Open Access | 10.1172/JCI170196

Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force

Quentin McAfee,¹ Matthew A. Caporizzo,² Keita Uchida,² Kenneth C. Bedi Jr.,¹ Kenneth B. Margulies,¹ Zolt Arany,³ and Benjamin L. Prosser²

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by McAfee, Q. in: JCI | PubMed | Google Scholar

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by Caporizzo, M. in: JCI | PubMed | Google Scholar |

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by Uchida, K. in: JCI | PubMed | Google Scholar |

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by Bedi Jr., K. in: JCI | PubMed | Google Scholar

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by Margulies, K. in: JCI | PubMed | Google Scholar |

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by Arany, Z. in: JCI | PubMed | Google Scholar |

¹Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

²Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

³Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America

Find articles by Prosser, B. in: JCI | PubMed | Google Scholar |

Published November 9, 2023 - More info

J Clin Invest. https://doi.org/10.1172/JCI170196.
Copyright © 2023, McAfee et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Published November 9, 2023 - Version history

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