c-Rel delivers a one-two punch in Th1 cell differentiation
Sung-Yun Pai, I-Cheng Ho
Sung-Yun Pai, I-Cheng Ho
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):741-742. https://doi.org/10.1172/JCI16552.
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c-Rel delivers a one-two punch in Th1 cell differentiation

Abstract

Commentary

Authors

Sung-Yun Pai, I-Cheng Ho

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Figure 1

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Signaling and transcriptional pathways of Th1 differentiation and the po...
Signaling and transcriptional pathways of Th1 differentiation and the potential role of c-Rel. Induction of T-bet and IFN-γ by T cell receptor engagement is followed by activation of the STAT4 and STAT1 pathways, which lead to still greater expression of IFN-γ. Points at which c-Rel could participate in this pathway are indicated.