Neutralizing antibody responses in patients hospitalized with SARS-CoV-2 Delta or Omicron infection
Susanne L. Linderman, … , Wesley H. Self, Rafi Ahmed
Susanne L. Linderman, … , Wesley H. Self, Rafi Ahmed
Published October 18, 2022
Citation Information: J Clin Invest. 2022;132(23):e164303. https://doi.org/10.1172/JCI164303.
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Research Letter

Neutralizing antibody responses in patients hospitalized with SARS-CoV-2 Delta or Omicron infection

Abstract

Authors

Susanne L. Linderman, Lilin Lai, Estefany L. Bocangel Gamarra, Max S.Y. Lau, Srilatha Edupuganti, Diya Surie, Mark W. Tenforde, James D. Chappell, Nicholas M. Mohr, Kevin W. Gibbs, Jay S. Steingrub, Matthew C. Exline, Nathan I. Shapiro, Anne E. Frosch, Nida Qadir, Meredith E. Davis-Gardner, M. Juliana McElrath, Adam S. Lauring, Mehul S. Suthar, Manish M. Patel, Wesley H. Self, Rafi Ahmed

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Figure 1

Live virus–neutralizing antibody titers in hospitalized patients infected with SARS-CoV-2 Delta or Omicron variants.

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Live virus–neutralizing antibody titers in hospitalized patients infecte...
In vitro neutralization titers against live WA1, Delta, BA.1, or BA.2 variants in unvaccinated (A and C) and vaccinated (B and D) hospitalized patients infected with a Delta (A and B) or Omicron (C and D) strain. Solid lines indicate sequence-confirmed infections; dashed lines, non-sequence-confirmed; red indicates immunocompromised patients. The ratio of BA.1- to WA1-neutralizing titers in unvaccinated (E) or vaccinated (F) patients. Geometric mean and 95% CI are indicated. For a subset of Omicron-infected patients who were unvaccinated (G) or vaccinated (H), BA.5 neutralization was also assessed. Values above the panels indicate fold differences between groups (P value). P values were calculated by Wilcoxon’s rank sum test.