Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Supplemental material
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Clinical MedicineIn-Press PreviewTherapeutics Open Access | 10.1172/JCI163548

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors

Agnes Bonifacius,1 Britta Lamottke,2 Sabine Tischer-Zimmermann,1 Rebecca Schultze-Florey,2 Lilia Goudeva,1 Hans-Gert Heuft,1 Lubomir Arseniev,3 Rita Beier,2 Gernot Beutel,4 Gunnar Cario,5 Birgit Fröhlich,6 Johann Greil,7 Leo Hansmann,8 Justin Hasenkamp,9 Michaela Höfs,10 Patrick Hundsdoerfer,11 Edgar Jost,12 Kinan Kafa,13 Oliver Kriege,14 Nicolaus Kröger,15 Stephan Mathas,16 Roland Meisel,17 Michaela Nathrath,18 Mervi Putkonen,19 Sarina Ravens,20 Hans Christian Reinhardt,21 Elisa Sala,22 Martin G. Sauer,2 Clemens Schmitt,8 Roland Schroers,23 Nina Kristin Steckel,24 Ralf Ulrich Trappe,25 Mareike Verbeek,26 Daniel Wolff,27 Rainer Blasczyk,1 Britta Eiz-Vesper,1 and Britta Maecker-Kolhoff2

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Bonifacius, A. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Lamottke, B. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Tischer-Zimmermann, S. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Schultze-Florey, R. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Goudeva, L. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Heuft, H. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Arseniev, L. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Beier, R. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Beutel, G. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Cario, G. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Fröhlich, B. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Greil, J. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Hansmann, L. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Hasenkamp, J. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Höfs, M. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Hundsdoerfer, P. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Jost, E. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Kafa, K. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Kriege, O. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Kröger, N. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Mathas, S. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Meisel, R. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Nathrath, M. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Putkonen, M. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Ravens, S. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Reinhardt, H. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Sala, E. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Sauer, M. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Schmitt, C. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Schroers, R. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Steckel, N. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Trappe, R. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Verbeek, M. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Wolff, D. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Blasczyk, R. in: JCI | PubMed | Google Scholar |

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Eiz-Vesper, B. in: JCI | PubMed | Google Scholar

1Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School (MHH), Hannover, Germany

2Department of Pediactric Hemtatology and Oncolocy, Hannover Medical School (MHH), Hannover, Germany

3Cellular Therapy Centre, Hannover Medical School (MHH), Hannover, Germany

4Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantatio, Hannover Medical School (MHH), Hannover, Germany

5Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany

6Pediatric Hematology and Oncology, University Children's Hospital Muenster, Münster, Germany

7Department of Hematology and Oncology, University Children's Hospital Heidelberg, Heidelberg, Germany

8Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

9Clinic for Hematology and Oncology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany

10Pediatric Hematology and Oncology, Department for Pediatrics III, University Hospital of Essen, Essen, Germany

11Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany

12Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplant, University Medical Center RWTH Aachen, Aachen, Germany

13Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, Halle, Germany

14Third Department of Medicine - Haematology, Internal Oncology & Pneumology, Johannes Gutenberg-University Medical Centre, Mainz, Germany

15Department for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16Charité - Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immuno, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

17Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, , Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany

18Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany

19Department of Hematology and Stem Cell Transplantation, Turku University Hospital, Turku, Finland

20Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany

21Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany

22Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

23Department of Hematology and Oncology, Knappschaftskrankenhaus University Hospital Bochum, Bochum, Germany

24Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany

25Department of Internal Medicine II-Hematology and Oncology, Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany

26Clinic and Policlinic for Internal Medicine III, Klinikum rechts der Isar, Munich, Germany

27Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany

Find articles by Maecker-Kolhoff, B. in: JCI | PubMed | Google Scholar |

Published May 9, 2023 - More info

J Clin Invest. https://doi.org/10.1172/JCI163548.
Copyright © 2023, Bonifacius et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published May 9, 2023 - Version history
View PDF
Abstract

BACKGROUND. Adoptive transfer of EBV-specific T cells can restore specific immunity in immunocompromised patients with EBV-associated complications.

METHODS. We provide results of a personalized T-cell manufacturing program evaluating donor, patient, T-cell product and outcome data. Patient-tailored clinical-grade EBV-specific cytotoxic T-lymphocyte (EBV-CTL) products from stem cell donors (SCD), related third party donors (TPD) or unrelated TPD from the allogeneic T-cell donor registry (alloCELL) established at Hannover Medical School were manufactured by immunomagnetic selection using CliniMACS Plus or Prodigy device and EBV PepTivators EBNA-1 and Select. Consecutive manufacturing processes were evaluated and patient outcome and side effects were retrieved by retrospective chart analysis.

RESULTS. Forty clinical-grade EBV-CTL products from SCDs, related or unrelated TPDs were generated for 37 patients with and without transplantation (Tx) history within 5 days (median) after donor identification. 34 patients received 1-14 EBV-CTL products (fresh and cryopreserved). EBV-CTL transfer led to complete response in 20 of 29 patients who were evaluated for clinical response. No infusion-related toxicity was reported. EBV-specific T cells in patients’ blood were detectable in 16/18 monitored patients (89 %) after transfer and correlated with clinical response.

CONCLUSION. In conclusion, personalized clinical-grade manufacturing of EBV-CTL products via immunomagnetic selection from SCD, related or unrelated TPD is feasible in a timely manner. Overall, EBV-CTL were clinically effective and well-tolerated. Our data suggest EBV-CTL as promising therapeutic approach for immunocompromised patients with refractory EBV-associated diseases beyond HSCT as well as patients with pre-existing organ dysfunction.

TRIAL REGISTRATION. Not applicable.

FUNDING. This study was in part funded by the German Research Foundation (DFG, 158989968/SFB 900), the Deutsche Kinderkrebsstiftung (DKS 2013.09), the Wilhelm-Sander-Stiftung (http://www.wilhelm-sander-stiftung.de, 2015.097.1), the Ellen-Schmidt-Program of the Hannover Medical School, and the German Federal Ministry of Education and Research (reference number: 01EO0802).

Graphical Abstract
graphical abstract
Supplemental material

View Supplemental Table 1A (clean copy)

View Supplemental Table 1B (clean copy)

View Supplemental Figure 1 + Figure Legend

Version history
  • Version 1 (May 9, 2023): In-Press Preview

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Supplemental material
  • Version history
Advertisement
Advertisement

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts