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ResearchIn-Press PreviewMetabolismOncology
Open Access | 
10.1172/JCI161713
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression
Dongmei Gou,1 Rui Liu,1 Xiaoqun Shan,1 Haijun Deng,1 Chang Chen,2 Jin Xiang,1 Yi Liu,1 Qingzhu Gao,1 Zhi Li,3 Ailong Huang,4 Kai Wang,4 and Ni Tang1
1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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Deng, H.
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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Chen, C.
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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Huang, A.
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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Wang, K.
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1Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical University, Chongqing, China
2Institute of Life Sciences, Chongqing Medical University, Chongqing, China
3Department of Breast and Thyroid Surgery, Chongqing Medical University, Chongqing, China
4Institute for Viral Hepatitis, Department of Infectious Diseases, Chongqing Medical Univesity, Chongqing, China
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Tang, N.
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Published May 11, 2023 - More info
Copyright © 2023, Gou et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)