Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection
Feng Lin, … , Chelliah Richmonds, M. Edward Medof
Feng Lin, … , Chelliah Richmonds, M. Edward Medof
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1269-1274. https://doi.org/10.1172/JCI16086.
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Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection

Abstract

Research Article

Authors

Feng Lin, Henry J. Kaminski, Bianca M. Conti-Fine, Wei Wang, Chelliah Richmonds, M. Edward Medof

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Figure 1

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Daf1–/– and Daf1+/+ mice were injected with McAb-3 24 hours prior to vid...
Daf1–/– and Daf1+/+ mice were injected with McAb-3 24 hours prior to videotaping (photographs shown were acquired from video images). (a) The Daf1–/– mouse had a hunched posture and could not extend its digits. Its hind limbs could not support its weight. This mouse had a hang time of less than 10 seconds. (b) The Daf1+/+ littermate was normally active (shadow under belly, turning body), showing normal posture and leg position. It had a hang time of more than 8 minutes.