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ResearchIn-Press PreviewImmunologyOncology
Open Access | 
10.1172/JCI160790
Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells
Xinyi Jiang,1 Jian Lin,2 Chengfang Shangguan,3 Xiaoyao Wang,1 Bin Xiang,4 Juan Chen,1 Hezhou Guo,1 Wu Zhang,1 Jun Zhang,3 Yan Shi,3 Jiang Zhu,5 and Hui Yang3
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Jiang, X. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Lin, J. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Shangguan, C. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Wang, X. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xiang, B.
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1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Chen, J. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Guo, H. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zhang, W. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zhang, J. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Shi, Y. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zhu, J. in: JCI | PubMed | Google Scholar
1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China
3Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
5Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Yang, H. in: JCI | PubMed | Google Scholar
Published March 16, 2023 - More info
Copyright © 2023, Jiang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)