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The functional CD8 T cell response to HIV becomes type-specific in progressive disease
Sang Kyung Lee, … , Judy Lieberman, Premlata Shankar
Sang Kyung Lee, … , Judy Lieberman, Premlata Shankar
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1339-1347. https://doi.org/10.1172/JCI16028.
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Categories: Article Aging

The functional CD8 T cell response to HIV becomes type-specific in progressive disease

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Abstract

Research Article

Authors

Sang Kyung Lee, Zhan Xu, Judy Lieberman, Premlata Shankar

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Figure 5

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Autologous virus–infected targets are not lysed by IFN-γ+ CD8 T cell lin...
Autologous virus–infected targets are not lysed by IFN-γ+ CD8 T cell lines responding to HIVIIIB virus and vice versa in samples from more advanced donors. Short-term cultures from IFN-γ+ cells responding to IIIB (a) or autologous virus (b) were tested against uninfected (black bars), IIIB (white bars), or autologous (gray bars) virus–infected primary CD4 T cell targets. Representative data for subjects from each CDC stage are depicted at effector/target ratios ranging from 1:1 to 5:1. Data are presented as mean of experiments performed in triplicate. The cytotoxicity assays confirm the results of TCRBV sequencing. There was cross-recognition of IIIB and autologous virus by two of the stage A donor cell lines, but not by the cell lines from more advanced donors.
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