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The functional CD8 T cell response to HIV becomes type-specific in progressive disease
Sang Kyung Lee, … , Judy Lieberman, Premlata Shankar
Sang Kyung Lee, … , Judy Lieberman, Premlata Shankar
Published November 1, 2002
Citation Information: J Clin Invest. 2002;110(9):1339-1347. https://doi.org/10.1172/JCI16028.
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Article Aging

The functional CD8 T cell response to HIV becomes type-specific in progressive disease

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Abstract

Research Article

Authors

Sang Kyung Lee, Zhan Xu, Judy Lieberman, Premlata Shankar

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Figure 1

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Flow cytometric analysis of MHC class I and p24 expression on HIV-infect...
Flow cytometric analysis of MHC class I and p24 expression on HIV-infected primary CD4 T cells used as stimulator cells. CD4 PHA blasts from representative subject 307 were used as uninfected control (a) or were infected with HIVIIIB (b), NL4-3 (c), or autologous virus (d) for 3 days and then enriched for infected cells by immunomagnetic depletion of cells that had not downmodulated CD4 expression. Cells were stained externally with PE-conjugated anti–HLA-ABC antibody (MHC class I framework) and internally with FITC-conjugated anti-p24 antibody.

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