FDC network areas in the spleen are significantly diminished following treatment with LTβR-Ig in all dose groups. Spleen sections stained with anti-CD35 Ab’s were subjected to morphometric analysis. FDC networks in the spleen (a and c) and LN (b) were quantified in terms of areas compared with overall tissue area. For D29 (day 29) data, 8-mg/kg intravenous and subcutaneous groups were combined. For recovery data (c), all doses were combined.