FDC networks in the spleen are eliminated in animals treated with LTβR-Ig. Representative spleens from untreated (a and b), treated (8 mg/kg LTβR-Ig) (c and d), and recovery animals (8 mg/kg treatment followed by 3-month recovery) (e and f) were stained with anti-CD35 Ab’s and developed with AP-red. Spleens were counterstained with Giemsa and photographed at ×25 (a, c, e) or ×100 (b, d, f).