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Research Article Free access | 10.1172/JCI1594

Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

H Abe, N Yamada, K Kamata, T Kuwaki, M Shimada, J Osuga, F Shionoiri, N Yahagi, T Kadowaki, H Tamemoto, S Ishibashi, Y Yazaki, and M Makuuchi

Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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First published April 15, 1998 - More info

Published in Volume 101, Issue 8 on April 15, 1998
J Clin Invest. 1998;101(8):1784–1788. https://doi.org/10.1172/JCI1594.
Copyright © 1998, The American Society for Clinical Investigation.

First published April 15, 1998 - Version history
Abstract

Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions. Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance.

Version history
  • Version 1 (April 15, 1998): No description
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